GeneMANIA: Fast gene network construction and function

The GeneMANIA Cytoscape app enables users to construct a composite gene-gene functional interaction network from a gene list. The resulting network includes the genes most related to the original list, and functional annotations from Gene Ontology. The edges are annotated with details about the publication or data source the interactions were derived from. The app leverages GeneMANIA’s database of 1800+ networks, containing over 500 million interactions spanning 8 organisms: A. thaliana, C. elegans, D. , and melanogaster, D. rerio, H. sapiens, M. musculus, R. norvegicus S. . Users may also import their own organisms, networks, and cerevisiae expression profiles. The app is compatible with Cytoscape versions 2 and 3. This article is included in the Cytoscape apps channel. Jason Montojo ( ) Corresponding author: [email protected] Montojo J, Zuberi K, Rodriguez H How to cite this article: et al. GeneMANIA: Fast gene network construction and function prediction for 2014, :153 (doi: ) Cytoscape [version 1; referees: 2 approved] F1000Research 3 10.12688/f1000research.4572.1 © 2014 Montojo J . This is an open access article distributed under the terms of the , which Copyright: et al Creative Commons Attribution Licence permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Data associated with the article are available under the terms of the (CC0 1.0 Public domain dedication). Creative Commons Zero "No rights reserved" data waiver This work was funded by the Ontario Government’s Ministry of Research and Innovation via the Global Leadership Round in Grant information: Genomics & Life Sciences (GL2) program (assigned to GDB and QM); and the National Resource for Network Biology (U.S. National Institutes of Health, National Center for Research Resources grant number P41 GM103504, assigned to GDB). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing interests: No competing interests were disclosed. 01 Jul 2014, :153 (doi: ) First published: 3 10.12688/f1000research.4572.1 Referee Status: